Work package 5: Validation of clinical predictors and models

Objectives

1. Validation of the predictive power of clinical predictors reported in the literature in existing cohorts of breast, prostate and lung patients available to the project partners and collaborators.

2. Replication of prediction models in multicentre studies designed to collect standardised toxicity data and non-genetic risk factor data.

3. Integration of in vitro patient radiosensitivity (biomarker) data in prediction models.

 

Deliverables

5.1) Report testing of predictive value risk factors, nomograms, multivariate logistic regression models and NTCP models reported in the literature in existing pt cohorts available to partners: Report testing of predictive value risk factors, nomograms, multivariate logistic regression models and NTCP models reported in the literature in existing patient cohorts available to project partners.

5.2) Report performance of validated prediction models including biomarkers in patient cohorts resulting from WP2.